GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1116547 | 1 | rs12516418 | chr5:112707789 | YTHDC2 | chr5:112849410-112930979:+ | 0.14 | 4.09 | 4.71E-5 | Cerebral amyloid angiopathy |
| BRCA | cis | rs3756766 | 1 | rs12517410 | chr5:137736611 | CDC25C | chr5:137620959-137674044:- | 0.09 | 3.71 | 0.00022 | Schizophrenia |
| BRCA | cis | rs6882076 | 1 | rs12517431 | chr5:156392248 | TIMD4 | chr5:156346293-156390266:- | -0.34 | -10.96 | 1.53E-26 | Triglycerides;Cholesterol, total;LDL cholesterol |
| BRCA | cis | rs10043228 | 1 | rs12517508 | chr5:115423574 | COMMD10 | chr5:115420727-115628978:+ | 0.23 | 4.87 | 1.29E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs1116547 | 1 | rs12519753 | chr5:112687407 | YTHDC2 | chr5:112849410-112930979:+ | 0.13 | 3.71 | 0.000221 | Cerebral amyloid angiopathy |
| BRCA | cis | rs1116547 | 1 | rs12519818 | chr5:112772041 | YTHDC2 | chr5:112849410-112930979:+ | 0.14 | 4.1 | 4.53E-5 | Cerebral amyloid angiopathy |
| BRCA | cis | rs10043228 | 1 | rs12519989 | chr5:115562642 | COMMD10 | chr5:115420727-115628978:+ | 0.23 | 4.93 | 9.54E-7 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10043228 | 1 | rs12520076 | chr5:115458830 | COMMD10 | chr5:115420727-115628978:+ | 0.25 | 4.86 | 1.34E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10043228 | 1 | rs12520568 | chr5:115621505 | COMMD10 | chr5:115420727-115628978:+ | 0.19 | 3.96 | 7.93E-5 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10043228 | 1 | rs12520632 | chr5:115591766 | COMMD10 | chr5:115420727-115628978:+ | 0.26 | 4.86 | 1.34E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10043228 | 1 | rs12521612 | chr5:115582605 | COMMD10 | chr5:115420727-115628978:+ | 0.24 | 4.6 | 4.75E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10043228 | 1 | rs12522027 | chr5:115616531 | COMMD10 | chr5:115420727-115628978:+ | 0.22 | 4.31 | 1.77E-5 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs2036402 | 1 | rs12522248 | chr5:156479426 | TIMD4 | chr5:156346293-156390266:- | -0.15 | -4.16 | 3.38E-5 | Hypertriglyceridemia |
| BRCA | cis | rs1116547 | 1 | rs12523255 | chr5:112722085 | YTHDC2 | chr5:112849410-112930979:+ | 0.14 | 4.25 | 2.35E-5 | Cerebral amyloid angiopathy |
| BRCA | cis | rs10043228 | 1 | rs12523347 | chr5:115572395 | COMMD10 | chr5:115420727-115628978:+ | 0.21 | 4.49 | 7.77E-6 | Asthma or chronic obstructive pulmonary disease |